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KMID : 1149220160240020108
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Korean Journal of Oriental Medical Prescription
2016 Volume.24 No. 2 p.108 ~ p.123
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The comparative studies on anti-obesity effects of Ephedrae Herba and Cyperi rhizoma in high fat diet fed mice
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Oh Mi-Jin
Lee Chang-Hyun
Kim Hong-Jun
Kim Ha-Rim
Kim Min-Sun
Lee Da-Young
Oh Chan-Ho
Kim Myung-Soon
Kim Jong-Seok
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Abstract
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Objectives : This comparative study was to investigate on anti-obesity effects of Ephedrae Herba and Cyperi rhizoma in high fat diet(HFD) fed mice.
Methods : Male C57BL/6J mice were fed a normal diet(normal group, N), high fat 45 cal% diet[HFD, control group, C), HFD with Ephedrae Herba(EH group) and Cyperi rhizoma(CR group) extracts fed for 5 weeks. We were observed as follows : changes of body weight, amount of diet intake, weight of total visceral fats, levels of obesity-related hormones and blood lipids.
Results : The change of body weight after EH and CR oral administration significantly more decreased in EH group than that of control group. The FFR(Food Efficiency Ratio) was decreased in EH group, but more increased in CR group than that of control group. The weight of periepididymal and perirenal fats were significantly decreased in EH and CR groups compared to the control group. The levels of serum leptin and insulin were significantly decreased in EH group, and the level of serum adiponectin was increased in EH group compared to control group. The levels of serum triglyceride and total cholesterol were significantly decreased in EH and CR groups, and HDL-cholesterol levels was significantly increased in EH group compared to control group. Conversely in CR group, its values showed the opposite effect. The staining density of lipid droplets within the hepatocytes was widely distributed in CR and control groups, but in EH group, its density was weakly stained.
Conclusions : These experimental results suggest that Ephedrae Herba shows conspicuous anti-obesity effect, and
Cyperi rhizoma shows weak anti-obesity effect.
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KEYWORD
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Ephedrae Herba, Cyperi rhizoma, anti-obesity, leptin, insulin, adiponectin, lipids
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